What is Steatosis? Where is it often seen?
Abnormal accumulations of triacylglycerides within paranchymal cells.
Seen in liver mostly, heart, and kidneys
How does Steatosis appear morphologically?
Cleared vacuoles within parenchymal cells, stained in orange-red colour using Sudan IV or Oil Red-O stains. The vacuoles displace the nucleus to the peripheral margins of the cell.
What causes the accumulation of cholesterol in Niemann-pick disease type C?
For some enzyme involved in cholesterol trafficking is mutated (Lysosomal storage disease)
What complication is seen in Diabetes Mellitus as for glycogen?
Accumulation of glycogen in the epithelial cells of the distal portions of the proximal convoluted tubules, hepatic cells, cardiac muscles, and beta cells of Langerhans
Where does carbon dust usually accumulate in the body? How would that affect?
It is being inhaled, picked up via macrophages, to the regional lymph nodes causing anthracrosis of the lung and lymph nodes.
What are the complications involved in worker's pneumoconiosis?
Accumulation of coal dust has induced fibroblastic reactions or emphysema, causing this dangerous lung disease.
Is lipofusin an injurious pigment? No.
How would it be used in medical applications?
It is a good telltale of free radical injury and lipid peroxidation
Where is Melanin derived from?
Tyrosine* Oxidation reaction is catalyzed via tyrosinase* to dihydroxyphenylalanine.
What is Hemosiderosis?
A situation of which Hemosidoerin pigment is accumulated in tissues.
What could cause Hemosiderosis?
1- Blood transfusion.
2- Impaired use of iron
3- Increased absorption of iron in diet
4- Hemolytic anemia.
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